Its inhibitory action in the amygdala is beneficial in anxiety disorders, while its inhibitory activity in the cerebral cortex is beneficial in seizure disorders.Ībsorption: lorazepam is well absorbed after oral administration. This shift in chloride ions results in hyperpolarization and stabilization of the cellular plasma membrane. It enhances the inhibitory effects of GABA, which increases the conductance of chloride ions in the cell. Lorazepam binds to benzodiazepine receptors on the postsynaptic GABA-A ligand-gated chloride channel neuron at several sites within the central nervous system (CNS).
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